Abstract: From its beginnings, ISSER has been concerned with generating new theory and empirical information on human development in Ghana and beyond. Very little prior work had been completed on adult health in Ghana and in urban places in particular. The first wave of the WHSA was conducted in 2003 and included a household survey of 3182 women and a clinical examination of 1328 women, drawn from the same cohort. The study involved the collection of information on both reproductive and general health from household interview surveys, comprehensive clinical history and physical examinations, as well as screening for heart disease, obesity, cervical cancer, breast cancer, hypercholesterolemia, diabetes, anemia and HIV. The study was designed to serve as a baseline for a subsequent series of more specific research and the evaluation of the impact of intervention projects on selected high priority health topics. The follow-up study, Wave II (WHSA-II) reported on here, builds on the detailed survey work from Wave I and was designed to obtain new empirical information on the links between health and wealth on the household level. New sub-studies were added on reproductive health; on time use and health; on health and well-being in slum areas; and on causes of death in the city. Novel features of the work included the integration of census, survey and routinely reported facility-based health data as well as information from the interpretation of satellite imagery.